Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Extrapyramidal disorder
ADR ID BADD_A01568
ADR Hierarchy
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.02      Dyskinesias and movement disorders NEC
17.01.02.007      Extrapyramidal disorder
Description A disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. [CTCAE] Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA. [MeSH]
MedDRA Code 10015832
MeSH ID D001480
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Benign shuddering attacks | Drug-induced extrapyramidal side effects | Extrapyramidal disorder | Extrapyramidal disorder (NOS) | Extrapyramidal disorder NEC | Extrapyramidal symptoms | Extrapyramidal syndrome | Extrapyramidal syndrome (NOS) | Other and unspecified extrapyramidal diseases and abnormal movement disorders | Other extrapyramidal disease and abnormal movement disorders | Other extrapyramidal diseases and abnormal movement disorders | Syndrome extrapyramidal | Unspecified extrapyramidal disease and abnormal movement disorder | Extrapyramidal disorder aggravate | Extrapyramidal disorder aggravated | Basal Ganglia Diseases | Basal Ganglia Disease | Basal Ganglia Disorders | Basal Ganglia Disorder | Extrapyramidal Disorders | Extrapyramidal Disorder | Lenticulostriate Disorders | Lenticulostriate Disorder
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Band 3 anion transport proteinP02730Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00951Fluvoxamine maleate--
BADD_D00970Fosphenytoin--
BADD_D00971Fosphenytoin sodium--
BADD_D00981Gabapentin--
BADD_D01004Ganciclovir sodium--
BADD_D01040Granisetron--
BADD_D01051Halobetasol--
BADD_D01054Haloperidol0.043827%
BADD_D01055Haloperidol decanoate--
BADD_D01056Haloperidol lactate--
BADD_D01132Idursulfase--
BADD_D01133Ifosfamide--
BADD_D01134Iloperidone0.000602%
BADD_D01139Imipramine--
BADD_D01140Imipramine hydrochloride--
BADD_D01141Imipramine pamoate--
BADD_D01167Interferon alfa-2b--
BADD_D01191Ipratropium0.000576%
BADD_D01232Ketorolac--
BADD_D01233Ketorolac tromethamine--
BADD_D01243Lamotrigine--
BADD_D01257Letrozole--
BADD_D01265Levetiracetam--
BADD_D01272Levocetirizine0.000585%
BADD_D01275Levofloxacin--
BADD_D01280Levomilnacipran hydrochloride--
BADD_D01303Lithium carbonate0.002044%
BADD_D01304Lithium cation--
BADD_D01305Lithium hydroxide--
BADD_D01318Lorazepam0.000123%
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